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Watch Intently (two)pentobarbital will minimize the extent or influence of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Sturdy CYP3A4 inducers could minimize suvorexant efficacy; if elevated suvorexant dose needed, will not exceed 20 mg/working dayAfter halting a CYP3A4 inducer, as being the effect